H2N2V1, Main, Exploration, bibRecord, 000C01

The pathogenesis of influenza virus infections: the contributions of virus and host factors

Identifieur interne : 000C01 ( Main/Exploration ); précédent : 000C00; suivant : 000C02

The pathogenesis of influenza virus infections: the contributions of virus and host factors

Auteurs : Satoshi Fukuyama [Japon] ; Yoshihiro Kawaoka [Japon, États-Unis]

Source :

Current opinion in immunology [ 0952-7915 ] ; 2011.

RBID : PMC:3163725

Abstract

Influenza viruses cause acute respiratory inflammation in humans and symptoms such as high fever, body aches, and fatigue. Usually these symptoms improve after several days; however, the 2009 pandemic H1N1 influenza virus [influenza A(H1N1)2009] is more pathogenic than seasonal influenza viruses and the pathogenicity of highly pathogenic H5N1 viruses is still higher. The 1918 influenza pandemic virus caused severe pneumonia, resulting in an estimated 50 million deaths worldwide. Several virulence factors have been identified in these virus strains, but host factors are also responsible for the pathogenesis of infections caused by virulent viruses. Here, we review the contributions of both virus and host factors to the pathogenesis of these viral infections.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163725

DOI: 10.1016/j.coi.2011.07.016
PubMed: 21840185
PubMed Central: 3163725

Affiliations:

Le document en format XML

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The pathogenesis of influenza virus infections: the contributions of virus and host factors

The pathogenesis of influenza virus infections: the contributions of virus and host factors

Source :

Abstract

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Le document en format XML

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